What is polymorphism in pharmaceutical?
Polymorphism is the ability of solid materials to exist in two or more crystalline forms with different arrangements or conformations of the constituents in the crystal lattice. More than 50% of active pharmaceutical ingredients (APIs) are estimated to have more than one polymorphic form [1,2].
Why is polymorphism important in drugs?
Polymorphic forms of drugs can prove interesting for drug developers because their thermodynamic and physicochemical properties, such as energy, melting point, density, stability, and in particular solubility, may offer an improvement on the original form.
What is polymorphism in drug discovery?
Polymorphism occurs when a chemical compound crystallizes with different internal structures. ICH Q6A defines polymorphism as “some new drug substances exist in different crystalline forms which differ in their physical properties.
What are examples of polymorphs?
Some common examples of polymorphs are calcite and aragonite. The composition of these two minerals is CaCO3, but calcite is rhombohedral while aragonite is orthorhombic. Diamond and graphite , both of which are pure carbon , are also polymorphs. Diamond, however, is cubic while graphite is hexagonal.
What is polymorphism and example?
The word polymorphism means having many forms. Real life example of polymorphism: A person at the same time can have different characteristic. Like a man at the same time is a father, a husband, an employee. So the same person posses different behavior in different situations. This is called polymorphism.
What is the significance of polymorphism?
Polymorphism usually functions to retain variety of form in a population living in a varied environment. The most common example is sexual dimorphism, which occurs in many organisms. Other examples are mimetic forms of butterflies (see mimicry), and human hemoglobin and blood types.
Which factors contribute to drug polymorphism?
Factors contributing to drug polymorphism among various ethnic groups can be loosely categorized as environmental, cultural, and genetic.
What do you understand by polymorphism?
Polymorphism is the ability of a programming language to present the same interface for several different underlying data types. Polymorphism is the ability of different objects to respond in a unique way to the same message.
How does polymorphism promote extensibility explain with example?
Polymorphism leverages extensibility. That means we can assign new classes with almost no modification of the existing code, provided the class is part of the inheritance hierarchy. For example, a Shape class contains a method called area().
What is the concept of polymorphism?
Polymorphism is the ability of any data to be processed in more than one form. The word itself indicates the meaning as poly means many and morphism means types. Polymorphism is one of the most important concept of object oriented programming language. Polymorphism is the key power of object-oriented programming.
What are the principles of polymorphism?
Polymorphism enables one entity to be used as as general category for different types of actions. The specific action is determined by the exact nature of the situation. The concept of polymorphism can be explained as “one interface, multiple methods”.
