What is Pletal 100mg used for?
Pletal is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. This medicine improves your ability to walk longer distances without pain. Pletal may also be used for purposes not listed in this medication guide.
Why is pletal contraindicated in heart failure?
PLETAL is contraindicated in patients with: Heart failure of any severity: Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV heart failure.
What are the side effects of cilostazol 100 mg?
Cilostazol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache.
- diarrhea.
- dizziness.
- heartburn.
- nausea.
- stomach pain.
- muscle pain.
Can cilostazol cause thrombocytopenia?
[18] Research has shown cilostazol to induce thrombocytopenia or leukopenia, progressing to agranulocytosis when drug administration does not immediately discontinue. Agranulocytosis is reversible with immediate discontinuation of the drug.
Is Pletal a blood thinner?
Cilostazol is an antiplatelet drug and a vasodilator. It works by stopping blood cells called platelets from sticking together and prevents them from forming harmful clots. It also widens blood vessels in the legs.
Can cilostazol cause heart failure?
Therefore, cilostazol is contraindicated for use in patients with heart failure. Megace (megestrol) is often used to help increase weight in our patient population. This medication has the potential to cause increase in fl uid retention, which could lead to an exacerbation of heart failure in our patients.
Is Pletal contraindicated in heart failure?
Pletal is contraindicated in patients with congestive heart failure of any severity. Pletal is contraindicated in patients with haemostatic disorders or active pathologic bleeding, such as bleeding peptic ulcer and intracranial bleeding. Pletal inhibits platelet aggregation in a reversible manner.
How long should cilostazol be taken?
You may need to use cilostazol for 1 to 3 months before it starts to work. If you see no improvement after using it for 3 months, then your provider will likely take you off it. You should not use cilostazol if you have heart failure.
What are the most common side effects of Pletal?
Table 1: Most Common Adverse Reactions in Patients on PLETAL (PLT) 50 or 100 mg Twice Daily (Incidence at least 2% and Occurring More Frequently (≥ 2%) in the 100 mg Twice Daily Group than on Placebo)
How many milligrams of Pletal should I take?
Pletal is for second-line use, in patients in whom lifestyle modifications (including stopping smoking and [supervised] exercise programs) and other appropriate interventions have failed to sufficiently improve their intermittent claudication symptoms. The recommended dosage of cilostazol is 100 mg twice a day.
When is the best time to take Pletal?
Recommended dosage The recommended dosage of PLETAL is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner.
When to discontinue the use of Pletal?
If symptoms are unimproved after 3 months, discontinue PLETAL. Reduce dose to 50 mg twice daily when coadministered with strong or moderate inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, erythromycin, and diltiazem) or inhibitors of CYP2C19 (e.g., ticlopidine, fluconazole, and omeprazole) [ see Drug Interactions ( 7.1 )]
