How fast should IVIG be infused?
5% IVIG products: For the first infusion, Flebogamma® 5% should be infused at a rate of 1 ml/kg/hour for the first 30 minutes. If there are no adverse reactions the rate can be increased every 30 minutes according to the table to a maximum rate of 6 ml/kg/hour (not to exceed 300 ml/hour).
How fast can you infuse Privigen?
The recommended initial infusion rate is 0.5 mg/kg/min (0.005 mL/kg/min). If the infusion is well tolerated, the rate may be gradually increased to a maximum of 8 mg/kg/min (0.08 mL/kg/min).
How do you infuse Privigen?
Privigen is for intravenous (IV) administration and should be infused by a separate infusion line. It should never be mixed with other IV medications, including other types of IVIg. Privigen may be diluted with D5W. Privigen should be at room temperature (up to 25° C [77° F]) at the time of administration.
How do you dilute IVIG?
If dilution prior to infusion is required, KIOVIG may be diluted with 5% glucose solution to a final concentration of 50 mg/ml (5% immunoglobulin).
What happens if you infuse IVIG too fast?
Anaphylaxis, another rare severe side effect, is a rapidly progressing, life-threatening allergic reaction that can be caused by either IVIG or SCIG infusions. Anaphylaxis may require the administration of corticosteroids and antihistamines, and in very severe cases, administration of epinephrine.
How long does IVIG stay in system?
How long does IVIG stay in your system? The half-life of IVIG in the body is, on average, about 25 days. It usually takes roughly 4-5 half-lives to clear the majority of IVIG from your body.
How is Privigen rate calculated?
Dosing calculator
- Loading dose: 2 g/kg (20 mL/kg) in divided doses over 2 to 5 consecutive days.
- Maintenance dose: 1 g/kg (10 mL/kg) administered in 1 to 2 infusions on consecutive days, every 3 weeks.
- ITP Dose: 1 g/kg (10 mL/kg) daily for 2 consecutive days.
- PI Dose: 200–800 mg/kg (2–8 mL/kg) every 3–4 weeks.
Why is immunoglobulin so expensive?
Controversy: Due to its high cost of manufacturing and administering the product, IVIG is an expensive therapy. The total cost of IVIG therapy ranges from $5000 to $10,000, depending on the patient’s weight and number of infusions per course. Additional costs may include a hospital stay if home infusion is not covered.
What are the side effects of IVIG?
One of the most common side effects is headache. Other side effects include chills, fever, flushing, flu-like muscle pains or joint pains, feeling tired, having nausea, vomiting, and rash.
How does IVIG work in autoimmune disease?
IVIg modulates the activation and effector functions of B and T lymphocytes, neutralizes pathogenic autoantibodies, interferes with antigen presentation and has a strong anti-inflammatory effect which depends on its interaction with the complement system, cytokines and endothelial cells.
Does IVIg weaken immune system?
IVIg may affect how your immune system reacts following any vaccination, and this can make the vaccine less effective. Because of this, it is best to avoid vaccinations for at least six weeks after having IVIg.
How long does IVIg stay in system?
The half-life of IVIG in the body is, on average, about 25 days. It usually takes roughly 4-5 half-lives to clear the majority of IVIG from your body.
