How DIC is different from TTP?
Thrombotic thrombocytopenic purpura (TTP) – hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy superficially like DIC, but distinctly different; in contrast to DIC, the mechanism of thrombosis is not via the tissue factor (TF)/factor VIIa pathway. Results of blood coagulation assays in TTP-HUS are normal.
Is TTP same as ITP?
Are ITP and TTP the same thing? No, ITP and TTP are not the same thing. Both ITP and TTP are bleeding disorders, but they occur for different reasons and may require different treatments.
What is the treatment for TTP?
Medicines used to treat TTP include glucocorticoids, vincristine, rituximab, and cyclosporine A. Sometimes surgery to remove the spleen (an organ in the abdomen) is needed. This is because cells in the spleen make the antibodies that block ADAMTS13 enzyme activity.
How is Microangiopathic hemolytic anemia treated?
The immediate treatment for TTP is emergent plasma exchange. In TTP, platelet transfusions can worsen the disease and should not be administered, unless life-threatening anemia or bleeding is present. Untreated TTP is fatal in 90% of cases.
Is there thrombocytopenia in DIC?
Typically, moderate-to-severe thrombocytopenia is present in DIC. Thrombocytopenia is seen in as many as 98% of DIC patients, and the platelet count can dip below 50 × 109/L in 50%.
How does DIC cause gangrene?
DIC arising from sepsis results in uncontrolled activation of the coagulation pathway, and the use of vasopressors simultaneously involves the creation of spasms that affect the vessels; these spasms aggravate microcirculation problems which result in gangrene [2].
How does a person get ITP?
Immune thrombocytopenia usually happens when your immune system mistakenly attacks and destroys platelets, which are cell fragments that help blood clot. In adults, this may be triggered by infection with HIV , hepatitis or H. pylori — the type of bacteria that causes stomach ulcers.
How long can you live ITP?
In the majority of people with ITP, the condition isn’t serious or life-threatening. Acute ITP in children often resolves within six months or less without treatment. Chronic ITP can last for many years. People can live for many decades with the disease, even those with severe cases.
How do you manage hemolytic anemia?
Treatments for hemolytic anemia include blood transfusions, medicines, plasmapheresis (PLAZ-meh-feh-RE-sis), surgery, blood and marrow stem cell transplants, and lifestyle changes. People who have mild hemolytic anemia may not need treatment, as long as the condition doesn’t worsen.
Is there a difference between ITP and TTP?
Both immune thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP) are disorders that affect platelets. They may exhibit similar symptoms, however there are differences in the causes, complications, and treatments of the disorders.
What is the difference between DiC and TTP?
DIC and TTP. DIC, also called consumption coagulopathy, is a systemic process producing both thrombosis and hemorrhage. Purpura fulminans is a severe form of DIC resulting from thrombosis of extensive areas of the skin.
What’s the difference between ITP and blood disorders?
ITP vs TTP. Blood disorders are conditions wherein the normal function of blood is affected. This disorder may involve factors that influence the production of blood components like hemoglobin or blood proteins. Blood disorders may also involve conditions where there is improper coagulation of the blood or the blood cells become infected.
How is thrombocytopenia different from TMA and DIC?
Among laboratory data, thrombocytopenia is observed in both DIC and TMA. A decreased hemoglobin level and increased levels of creatinine, total bilirubin and LDH are observed in most patients with TMA, but these abnormalities are observed in only 15% of patients with DIC.
