What is the shelf life of amphotericin?
Specifications
| Product Type: | Antifungal |
|---|---|
| Validated Application: | Prevention of Cell Culture Contamination |
| Product Line: | Fungizone™ |
| Form: | Liquid |
| Shelf Life: | 12 Months |
Does amphotericin B expire?
Depending on the type of amphotericin B prescribed, the solution will be stable for 6 to 48 hours. Consult your pharmacist to know when your bags or bottles of amphotericin B will expire. Keep well out of the reach of children.
Does amphotericin B need to be refrigerated?
Prior to reconstitution Amphotericin B Intravenous should be stored in the refrigerator, protected against exposure to light. The reconstituted solution may be stored in the dark, at room temperature for 24 hours, or at refrigerator temperatures for 1 week with minimal loss of potency and clarity.
How do you store amphotericin B?
The concentrate (5 mg amphotericin B per mL after reconstitution with 10 mL Sterile Water for Injection, USP) may be stored in the dark, at room temperature for 24 hours, or at refrigerator temperatures for 1 week with minimal loss of potency and clarity. Any unused material should then be discarded.
Can amphotericin B be mixed with normal saline?
Procedure: Prehydration: Give 1 litre of Normal Saline with 1 amp (20mmol) of KCl infused over 2 hours before the Amphotericin B infusion. This reduces the risk of renal toxicity and hypokalaemia, both side effects of Amphotericin B. This should preferably be given from 8am to 10am.
Can Amphotericin B be given orally?
Amphotericin B can be given intravenously, orally or topically. It is not absorbed at all after oral or topical administration and so this mode of delivery is simply for prophylaxis or the treatment of mucosal infection.
What is the major side effect of Amphotericin B?
Side Effects Fever, shaking, chills, flushing, loss of appetite, dizziness, nausea, vomiting, headache, shortness of breath, or fast breathing may occur 1 to 3 hours after the infusion is started.
What are the side effects of Amphotericin B?
More common
- Fever and chills.
- headache.
- increased or decreased urination.
- irregular heartbeat.
- muscle cramps or pain.
- nausea.
- pain at the place of injection.
- unusual tiredness or weakness.
Where to store amphotericin B for injection USP?
Prior to reconstitution Amphotericin B for Injection USP should be stored under refrigeration, 2° to 8°C (36°to 46°F), protected against exposure to light.
How is amphotericin B prepared for AmBisome injection?
AmBisome must be reconstituted using Sterile Water for Injection, USP (without a bacteriostatic agent). Vials of AmBisome containing 50 mg of amphotericin B are prepared as follows: 1. Aseptically add 12 mL of Sterile Water for Injection, USP to each AmBisome vial to yield a preparation containing 4 mg amphotericin B/mL.
How is amphotericin B diluted in dextrose injection?
Shake the vial immediately until the colloidal solution is clear. The infusion solution, providing 0.1 mg amphotericin B per mL, is then obtained by further dilution (1:50) with 5% Dextrose Injection, USP of pH above 4.2. The pH of each container of Dextrose Injection should be ascertained before use.
How long does it take to get steady state amphotericin B?
Steady state concentrations were generally achieved within 4 days of dosing. Although variable, mean trough concentrations of amphotericin B remained relatively constant with repeated administration of the same dose over the range of 1 to 5 mg/kg/day, indicating no significant drug accumulation in the serum.
