What drugs are neuromuscular blocking?
List of Neuromuscular blocking agents:
| Drug Name | Avg. Rating | Reviews |
|---|---|---|
| Zemuron (Pro) Generic name: rocuronium | No reviews | |
| Quelicin (Pro) Generic name: succinylcholine | No reviews | |
| Nuromax Generic name: doxacurium | No reviews | |
| Nimbex (Pro) Generic name: cisatracurium | 5.0 | No reviews |
Which drugs will block neuromuscular junction?
Neuromuscular blocking agents (NMBAs) come in two forms: depolarizing neuromuscular blocking agents (e.g., succinylcholine) and nondepolarizing neuromuscular blocking agents (e.g., rocuronium, vecuronium, atracurium, cisatracurium, mivacurium).
What is the most commonly used neuromuscular blocker?
Commonly used nondepolarizing agents are curare (long-acting), pancuronium (long-acting), atracurium (intermediate-acting), and vecuronium (intermediate-acting). Neuromuscular blocking agents are used clinically to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery.
What drugs are used to intubate?
[4] Common sedative agents used during rapid sequence intubation include etomidate, ketamine, and propofol. Commonly used neuromuscular blocking agents are succinylcholine and rocuronium. Certain induction agents and paralytic drugs may be more beneficial than others in certain clinical situations.
What are the side effects of neuromuscular blocking agents?
Acetylcholine plays a role in histamine release, muscarinic activation, vagolytic action, and norepinephrine release. As a result, side effects such as tachycardia and bradycardia, hypertension and hypotension, and bronchodilation and bronchospasm have been seen with their use (TABLE 1).
What are neuromuscular blocking agents used for?
Neuromuscular blocking agents (NMBAs) are usually administered during anesthesia to facilitate endotracheal intubation and/or to improve surgical conditions.
What is the difference between depolarizing and nondepolarizing neuromuscular blocking agents?
Depolarizing muscle relaxants act as acetylcholine (ACh) receptor agonists, whereas nondepolarizing muscle relaxants function as competitive antagonists.
How do you reverse neuromuscular blocking agents?
Sometimes, acetylcholinesterase inhibitors, most commonly neostigmine, are administered to reverse the neuromuscular blockade. Using acetylcholinesterase inhibitors increases the amount of acetylcholine in the synaptic cleft and thus counteracts the effects of neuromuscular blocking agents (NMBAs).
Do you give sedative or paralytic first?
It is commonly recommended that the sedative agent be administered before the paralytic agent. However, administration of the paralytic agent first may allow for decreased apnea time and increased first-pass success by shortening the time between the start of RSI drug administration and paralysis.
Why are muscle relaxants used for intubation?
Muscle relaxants are frequently used to facilitate endotracheal intubation during anesthesia induction. However, the administration of short-acting depolarizing muscle relaxants is closely related to postoperative myalgias, malignant hyperthermia, hyperkalemia, and increased intracranial or intraocular pressure.
Why would a patient receive a neuromuscular blocking agent?
Neuromuscular blocking agents (NMBAs) are hydrophilic drugs that are commonly used in clinical practice for paralysis in rapid sequence intubation, tracheostomy, to facilitate mechanical ventilation in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), and to prevent and treat …
Which of the following are examples of Nondepolarizing neuromuscular blocking agents?
Neuromuscular-Blocking Agents (Nondepolarizing)
| Drug | Target | Type |
|---|---|---|
| Pipecuronium | Cholinesterase | enzyme |
| Vecuronium | P-glycoprotein 1 | transporter |
| Vecuronium | Neuronal acetylcholine receptor subunit alpha-2 | target |
| Cisatracurium | Neuronal acetylcholine receptor subunit alpha-2 | target |
When to use neuromuscular blocking agent for emergent tracheal intubation?
Wilcox SR, Bittner EA, Elmer J, et al. Neuromuscular blocking agent administration for emergent tracheal intubation is associated with decreased prevalence of procedure-related complications. Crit Care Med 2012; 40:1808.
What are the two classes of neuromuscular blocking agents?
• Two classes of neuromuscular blocking agents – Non-depolarizing agents (aka curariform) competitively engage the receptor site in the muscle cell, blocking the action of acetylcholine – Depolarizing agents initially instigate muscle contraction, then sustain depolarization time (receptors cannot respond)
When to use Rapid Sequence Intubation ( RSI )?
In most circumstances, emergency clinicians use rapid sequence intubation (RSI) when active airway management is required. RSI incorporates neuromuscular blocking agents (NMBA) and rapidly acting sedative (ie, induction) medications to create optimal intubating conditions.
How are airway intubations used in the emergency department?
Sagarin MJ, Chiang V, Sakles JC, et al. Rapid sequence intubation for pediatric emergency airway management. Pediatr Emerg Care 2002; 18:417. Sakles JC, Laurin EG, Rantapaa AA, Panacek EA. Airway management in the emergency department: a one-year study of 610 tracheal intubations.
