What is signal specificity?
We defined the specificity of a pathway as the ratio of its authentic output to its spurious output, and the fidelity of a pathway as its output when given an authentic signal divided by its output in response to a spurious signal.
What factors determine the specificity of a signal response?
Factors that determine signal specificity in this system are poorly understood. Such factors include the relative affinity and stoichiometry of R-G or G-E and the possible colocalization of R-G-E in cellular microdomains.
What is involved in specificity of signal transduction?
Specificity in signaling by serine/threonine kinases. RTKs and other cell surface receptors, frequently activate protein serine/threonine kinases that convey the signal to targets in the cytoplasm and nucleus. Similar cascades of protein kinases lead to the activation of other MAPKs, such as Jnk/Sap or p38.
What accounts for the specificity of cell signaling?
Cell specificity results from the existence in any cell type of a unique set of proteins and their isoforms at each level of signal transduction cascades, from the space structure of their components, from their combinatorial logic at each level, from the presence of modulators of signal transduction proteins and of …
What determines receptor specificity?
Binding of an extracellular signal to its receptor involves the same type of interactions as those between an enzyme and its substrate. Receptor specificity depends on the binding affinity between the ligand and the binding site on the receptor.
What is the difference between selectivity and specificity in pharmacology?
For example a selective drug would have the ability to discriminate between, and so affect only one cell population, and thereby produce an event. Specificity, a term most often confused with selectivity, will be used to describe the capacity of a drug to cause a particular action in a population.
What causes receptor specificity?
What is specificity in cells?
Cell specialization means simply that cells may differ from one another, becoming specialized for a particular structure and function within the whole plant. From: Plant Systematics (Second Edition), 2010.
What is the difference between ligand and agonist?
In the last Pharmacology Corner we introduced ligands (the molecules that bind to receptors). Ligands that activate a receptor to produce a biological response are called agonists.
What are the three types of drug interactions?
Drug interactions can be categorised into 3 groups:
- Interactions of drugs with other drugs (drug-drug interactions),
- Drugs with food (drug-food interactions)
- Drug with disease condition (drug-disease interactions).
