What paraneoplastic syndromes are associated with lung cancer?
Endocrine syndromes, particularly syndrome of inappropriate ADH secretion (SIADH) and humoral hypercalcemia of malignancy (HHM) are the most common paraneoplastic syndromes seen in lung cancer and are related to the histologic type of cancer (1).
Can lung cancer cause neurological problems?
Neurologic complications of lung cancer are a frequent cause of morbidity and mortality. Tumor metastasis to the brain parenchyma is the single most common neurologic complication of lung cancer, of any histologic subtype.
What are paraneoplastic syndromes examples?
Paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis, myasthenia gravis, cerebellar degeneration, limbic or brainstem encephalitis, neuromyotonia, opsoclonus, and sensory neuropathy.
What is Lambert Eaton syndrome?
Lambert-Eaton myasthenic syndrome (LEMS) is a very rare condition that affects the signals sent from the nerves to the muscles. It means the muscles are unable to tighten (contract) properly, resulting in muscle weakness and a range of other symptoms.
Is paraneoplastic syndrome fatal?
The disease may be fatal if undiagnosed, but the prognosis is good if the teratoma is removed and immunomodulatory therapy is initiated. Detection of antibodies against NMDA receptors in the serum or CSF confirm the diagnosis [Dalmau et al. 2007].
How do you treat paraneoplastic syndrome?
How are paraneoplastic syndromes managed or treated?
- Corticosteroids: Medications that reduce inflammation (swelling)
- Immunosuppression: Drugs that manage the autoimmune response.
- Intravenous immunoglobulin: Healthy antibodies delivered through a needle into a vein that help destroy the antibodies causing the syndrome.
What causes Horner syndrome?
Horner syndrome is caused by damage to a certain pathway in the sympathetic nervous system. The sympathetic nervous system regulates heart rate, pupil size, perspiration, blood pressure and other functions that enable you to respond quickly to changes in your environment.
