Can SSRI cause low sodium?
Conclusion: Hyponatremia is a potentially dangerous side effect of antidepressants and is not exclusive to SSRIs. Current evidence suggests a relatively higher risk of hyponatremia with SSRIs and venlafaxine, especially when combined with patient risk factors, warranting clinicians to be aware of this complication.
What is meant by Dilutional hyponatremia?
Dilutional hyponatremia, also known as water intoxication, is a potentially life-threatening condition which occurs when a person consumes too much water without an adequate intake of electrolytes.
Which SSRI causes least hyponatremia?
All antidepressants except mianserin are associated with hyponatremia. The association is strongest with citalopram and lowest with duloxetine, venlafaxine and mirtazapine.
Can fluoxetine cause low sodium levels?
Conclusions: Using fluoxetine can decrease serum sodium level, which is more frequent, more severe, and more clinically manifested in older than younger patients. Monitoring serum sodium level is recommended in early weeks of fluoxetine therapy especially for patients older than 55 years of age.
What is the best antidepressant option for an elderly patient with history of chronic hyponatremia?
In patients at risk for or with a history of antidepressant-induced hyponatremia, bupropion may be the most appropriate antidepressant treatment. Mirtazapine could be also used alternatively because the associated risk of hyponatremia is moderate.
How long does it take for SSRI to cause hyponatremia?
In summary, these 35 articles reported a correlation between SSRI use and hyponatremia. The median time to onset of hyponatremia was 13 days (range 3–120 days). In all cases the patient’s condition returned to normal 2 to 28 days after discontinua- tion of the SSRI.
Why do SSRIs cause hyponatremia?
The mechanism by which SSRIs cause hyponatremia is thought to be secondary to development of SIADH. Treatment of isovolemia hypotonic hyponatremia associated with SSRI use includes water restriction and mild diuresis with a loop diuretic.
Is there a link between SSRIs and hyponatremia?
Current evidence suggests a relatively higher risk of hyponatremia with SSRIs and venlafaxine, especially when combined with patient risk factors, warranting clinicians to be aware of this complicat … Hyponatremia is a potentially dangerous side effect of antidepressants and is not exclusive to SSRIs.
What are the risks of taking mirtazapine for hyponatremia?
The risks associated with mirtazapine are moderate, supporting this antidepressant as an alternative treatment for patients with (an increased risk of) hyponatremia. Copyright © 2014 The Academy of Psychosomatic Medicine.
Is it possible for hyponatremia to recur?
In some, but not all, cases hyponatremia recurred. Conclusions: Practitioners should be on the alert for this potentially life-threatening adverse event, especially in older adults with other risk factors for developing hyponatremia. Publication types
Why is hyponatremia most commonly encountered in psychiatric patients?
ABSTRACT: Hyponatremia, the most commonly encountered electrolyte disorder in clinical practice, is associated with increased mortality. This harmful medical comorbidity is often overlooked and untreated in psychiatric patients. In these particular patients, hyponatremia is associated with psychogenic polydipsia.
