What constitutes a positive result with the acid phosphatase tartrate resistant stain?
A positive result means that your bones are breaking down for some reason. If you have other tests that show you have hairy cell leukemia, it will help confirm the diagnosis.
What does tartrate resistant acid phosphatase do?
The ACP5 gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells.
What does TRAP test mean?
Tartrate resistant acid phosphatase
Definition. Tartrate resistant acid phosphatase (TRAP) is a test performed on blood cells or bone marrow (biopsy) to confirm a diagnosis of hairy cell leukemia. This test can also be done on blood plasma to look for signs of bone breakdown.
What is TRAP positive?
Tartrate resistant acid phosphatase (TRAP) positive cells in rheumatoid synovium may induce the destruction of articular cartilage.
What does trap stain do?
The TRAP Staining Kit (cat. #AK04) is used for the staining of tartrate-resistant acid phosphatase in osteoclasts. Bone mass is controlled by the balance between the activity of osteoblasts and the activity of osteoclasts.
What is mean by leukocyte acid phosphatase?
A leukocyte alkaline phosphatase (LAP) test is a laboratory test that can be conducted on a sample of your blood. Your doctor can order it to measure the amount of alkaline phosphatase, a group of enzymes, in certain white blood cells.
What does TRAP stain do?
What does TRAP do in osteoclasts?
Cell growth and differentiation factor. TRAP is associated with osteoclast migration to bone resorption sites, and, once there, TRAP is believed to initiate osteoclast differentiation, activation, and proliferation. This hypothesis was formed from the examination of the bone structure of TRAP-null mice.
What does the T stand for in Traap?
The word TRAAP is an easy to remember acronym that stands for Timeliness, Relevance, Authority, Accuracy, and Purpose.
What is TRAP activity?
Tartrate-resistant acid phosphatase (TRAP) activity is regarded as an important cytochemical marker of osteoclasts; its concentration in serum is utilized as a biochemical marker of osteoclast function and degree of bone resorption. Serum TRAP activity was determined by spectrophotometric assay.
What is a normal lap score?
Scores for the LAP test can range from zero to 400, with those between 20 and 100 being considered normal. A score that’s higher than normal may be caused by: leukemoid reaction.
What does increased leukocyte alkaline phosphatase mean?
The leukocyte alkaine phosphatase (LAP) score is often used in patients with an elevated WBC to differentiate a reactive process from chronic myelogenous leukemia. The score in the latter is low while it is within the normal reference range or elevated in the former condition.
