How do you calculate Vanc trough?
To increase the therapeutic utility of an early vancomycin trough concentration, an estimate of the true trough can be determined by extrapolating the measured value using e−Kt, where K = CrCl × 0.00083 + 0.0044 and t is the time difference in hours.
How is Vanc half-life calculated?
Other pharmacists use the half-life (t1/2) equation (t1/2 = 0.693/Kel) to estimate how long to wait to reach the goal trough, using the Matzke equation to calculate the elimination constant (Kel) for vancomycin1: Kel=0.00083×(CrCl)+0.0044, Thus,t1/2=0.6930.00083×(CrCl)+0.0044.
How is vancomycin dosed?
Typically 15 to 20 mg/kg every 8 to 12 hours for most patients (based on actual body weight, rounded to the nearest 250 mg increment). In general, the approach to establishing the vancomycin dose/interval is guided by a nomogram.
How do you calculate AUC MIC ratio for vancomycin?
The empiric AUC:MIC ratio for a vancomycin dosing regimen can be predicted in advance by a simple formula: First, divide the total daily dose of vancomycin by the estimated clearance of vancomycin. Then divide this number by the MIC.
What is red neck syndrome?
Red man syndrome is the most common adverse reaction to the drug vancomycin (Vancocin). It’s sometimes referred to as red neck syndrome. The name comes from the red rash that develops on the face, neck, and torso of affected people. Vancomycin is an antibiotic.
What is peak and trough levels?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
How do you calculate 1/2 life of a drug?
The half-life (t1/2) is the time it takes for the plasma concentration of a drug or the amount of drug in the body to be reduced by 50%. The half-life of a drug can be determined using the following equation: t1/2 = (0.7 x Vd) / Cl, where Vd is volume of distribution and Cl is clearance.
How is clearance calculated?
Clearance is equal to the rate at which a drug is removed from plasma(mg/min) divided by the concentration of that drug in the plasma (mg/mL).
What is the normal range for vancomycin trough?
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 5-15 mcg/mL.
How fast do you infuse vancomycin?
Vancomycin should be infused slowly in a dilute solution (2.5 to 5.0 mg/ml) at a rate no greater than 10 mg/min and over a period not less than 60 minutes to avoid rapid infusion-related reactions. Stopping the infusion usually results in a prompt cessation of these reactions.
What is the AUC MIC ratio?
The pharmacodynamic parameter that is thought to best predict vancomycin efficacy is the ratio of the 24-hour area under the concentration-time curve to MIC (here referred to as AUC/MIC) (10–13).
What does AUC MIC ratio mean?
AUC:MIC – A combination of both T>MIC and Peak:MIC. The rate of bacterial killing is both related to the amount of time above the MIC and the total exposure of antibiotic to the organism. Prototypical antibiotic: fluoroquinolones.
